Model 2a, I-NaP and I-KM Sensitivites
Examination of the spike number contour surface defined by variations in maximum I-NaP and I-KM conductances over different input delays revealed a dependence of the graded spike number response on the ratio between these two conductances similar to that seen for models 1a and 1b (figures 21a, 21b). However, an area of uncontrolled repetetive firing on the I-NaP / I-KM contour surface for this model was seen when maximum conductances for both channel types approached zero (figures 21a, 21b). This is consistent with the finding of D’Angelo et al (2001) that bursting activity in the electrotonically compact granule cell requires the presence of both the slow K+ and persistent Na+ conductances.
