Preliminary Model
A single compartment granular cell model was created with default ionic conductances taken from the D’Angelo et al (2001) model of rat cerebellar granular cell bursting and resonance. As a test of this preliminary model, a constant current of 0.0057nA was applied to the cell over a 300ms time window and ionic conductances were varied in an attempt to modulate spike frequency and spike number within the resulting burst. With default conductance levels (see appendix, supplementary methods table 1), a burst containing 5 spikes with a duration of approximately 80ms was produced (figure 4a-ii). Onset and offset of the burst were produced by the balance between the slow, noninactivating Na+ and K+ conductances, I-NaP and I-KM (figure 4b-i). Spike attenuation and recovery during the burst were modulated by the I-KCa and I-CaHVA system, as shown in current traces (figure 4c).
